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Day 1: May 27th, 2021 (Thursday) |
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Opening Remarks（15:10〜15:20）
| Eiichi Araki |
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（Director of Center for Metabolic Regulation of Healthy
Aging (CMHA), Kumamoto University） |
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Session 1: Cancer Research（15:20〜17:40）
| Chairpersons： |
Hideo Baba
Toshiro Moroishi |
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（Kumamoto University）
（Kumamoto University） |
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Oncoproteins orchestrate immunosuppressive stroma in gastric adenocarcinoma |
| Jaffer A. Ajani |
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（The University of Texas MD Anderson Cancer
Center, USA） |
Development of therapeutic strategies targeting cancer stem cells |
| Hideyuki Saya |
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（Keio University, Japan） |
Elucidation of CAFs-orchestrated immunosuppressive microenvironment
in scirrhous gastric cancer stroma |
| Takatsugu Ishimoto |
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（Kumamoto University, Japan） |
Common genomic profiles identified by molecular profiling in two distinct sets of tumors |
| Tetsuo Noda |
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（Japanese Foundation for Cancer Research (JFCR),
Japan） |
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Poster Session（17:40〜18:40）
＊See below for titles and speakers.
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Day 2: May 28th, 2021 (Friday) |
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Session 2: Neuroscience Research（9:20〜12:00）
| Chairpersons： |
Kazuhito Tomizawa
Mitsuharu Ueda |
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（Kumamoto University）
（Kumamoto University） |
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Guided inhibition of BACE1 for Alzheimer's treatment |
| Riqiang Yan |
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（University of Connecticut School of Medicine, USA） |
Molecular pathology and disease-modifying therapies of Alzheimer's disease |
| Takeshi Iwatsubo |
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（The University of Tokyo, Japan） |
The Quest for the Holy Grail：Cutting-Edge Multifaced Therapeutic
Approaches to Cerebral Amyloid Angiopathy |
| Yasuteru Inoue |
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（Department of Neuroscience, Mayo Clinic, USA） |
Deciphering neurodevelopmental disorders by profiling mRNA translation in neurons |
| Motomasa Tanaka |
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（RIKEN, Japan） |
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Session 3: Metabolic, Cardiovascular and Aging Research (1)
（13:00〜15:00）
| Chairpersons： |
Eiichi Araki
Kyoko Miura |
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（Kumamoto University）
（Kumamoto University） |
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Single-cell transcriptomics of human aging defines the molecular basis of beta-cell differentiation in type 2 diabetes |
| Klaus H. Kaestner |
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（University of Pennsylvania Perelman School of
Medicine, USA） |
A Concerted Thermogenic Response via A Phosphor-switch of An
Epigenetic Modifier |
| Juro Sakai |
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（Tohoku University, The University of Tokyo (dual), Japan） |
Role of insulin receptor signaling on pancreatic exocrine cells in insulin resistance and diabetic state |
| Kazuki Fukuda |
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（Kumamoto University, Japan） |
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Coffee Break（15:00〜15:30） |
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Session 3: Metabolic, Cardiovascular and Aging Research (2)
（15:30〜17:30）
| Chairpersons： |
Yuichi Oike
Kenichi Tsujita |
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（Kumamoto University）
（Kumamoto University） |
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Vascular endothelial stem cells in health and ageing |
| Nobuyuki Takakura |
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（Osaka University, Japan） |
Emerging roles of ketone body metabolism |
| Yuichiro Arima |
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（Kumamoto University, Japan） |
Nicotinamide Mononucleotide
Its Biology and Potential as the First Anti-Aging Compound Translated to Humans |
| Shin-ichiro Imai |
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（Washington University School of Medicine, USA） |
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Closing Remarks（17:30〜17:40）
| Kazuhito Tomizawa |
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（Trustee & Vice President, Kumamoto University） |
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Poster Session |
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| 1． | A novel lncRNA ‘Caren’ antagonizes heart failure by inactivating ATM-DNA damage response and activating mitochondrial biogenesis. |
| Michio Sato |
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（Department of Molecular Genetics Graduate School of
Medical Sciences Kumamoto University, Japan ） |
| 2． | Proinsulin as a biomarker of β-cell aging |
| Yoshifumi Sato |
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（Department of Medical Biochemistry
Kumamoto University, Kumamoto, Japan） |
| 3． | Fusobacterium nucleatum promotes esophageal squamous cell carcinoma progression via the NOD1-NF-κB pathway |
| Yoshifumi Baba |
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（Department of Gastroenterological surgery
Kumamoto University, Kumamoto, Japan） |
| 4． | Colonization of distant organs by tumor cells generating circulating homotypic clusters adaptive to fluid shear stress |
| Satoru Shinriki |
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（Department of Molecular Laboratory Medicine
Kumamoto University, Kumamoto, Japan） |
| 5． | Dual functions of angiopoietin-like protein 2 signaling in tumor progression and anti-tumor immunitys |
| Haruki Horiguchi |
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（Department of Aging and Geriatric Medicine /
Department of Molecular Genetics
Kumamoto University, Kumamoto, Japan） |
| 6． | How can tRNA methylation dysfunction cause intellectual disability? And how can we cure the disease? |
| Takeshi Chujo |
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（Department of Molecular Physiology
Kumamoto University, Kumamoto, Japan） |
| 7． | Involvement of renal tubular NFAT5 in the regulation of blood pressure |
| Yuichiro Izumi |
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（Department of Nephrology Kumamoto University
Graduate School of Medical Sciences,
Kumamoto, Japan） |
| 8． | Discordant evolution of primate retroviruses is associated with their pathogenesis |
| Takafumi Shichijo |
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（Department of Hematology,
Rheumatology and Infectious Diseases
Kumamoto University, Kumamoto, Japan） |
| 9． | Single-cell analysis reveals ROR1 expressed tumor-initiating cells in pancreatic cancer. |
| Masaya Yamazaki |
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（Department of Medical Biochemistry /
Department of Cancer Biology,
Kumamoto University, Kumamoto, Japan） |
| 10． | Human Epididymis Protein 4 Causes Progressive Interstitial Fibrosis |
| Masahiro Yamamoto |
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（Department of Cardiovascular Medicine,
Graduate School of Medical Sciences,
Kumamoto University, Kumamoto, Japan） |
| 11． | Fusobacterium nucleatum promotes progression of esophageal squamous cell carcinoma via NF-κB pathway. |
| Daichi Nomoto |
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（Department of Gastroenterological Surgery
Kumamoto University, Kumamoto, Japan） |
| 12． | The role of SIRT7 in Alzheimer disease |
| Hironori Mizutani |
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（Department of Medical Biochemistry
Kumamoto University, Kumamoto, Japan） |
| 13． | Role of LSD1 in skeletal muscle plasticity under environmental stress |
| Hirotaka Araki |
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（Medical Cell Biology
Kumamoto University, Kumamoto, Japan） |
| 14． | A Novel ATP-retaining compound, KUS121, exerts renoprotective effects in ischemia-reperfusion injury in mice. |
| Yusuke Hata |
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（Department of Nephrology Kumamoto University
Graduate School of Medical Sciences,
Kumamoto, Japan） |
| 15． | Evaluation of the risk of HTLV-1-associated diseases by analyzing the host immune response |
| Asami Yamada |
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（Department of Hematology, Rheumatology,
and Infectious Diseases Kumamoto University,
Kumamoto, Japan） |
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